KLF10 Antibody Blocking Peptide(bs-21776P)-500ug

KLF10 Antibody Blocking Peptid

e(bs-21776P)-500ug
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  • ¥880
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  • bs-21776P
  • 2025年10月16日
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      500ug

    产品编号bs-21776P
    英文名称KLF10 Antibody Blocking Peptide
    中文名称TGF-β诱导早期应答基因1封闭多肽
    英文别名TIEG1; TGF-beta inducible early growth response gene 1; Transforming growth factor-beta-inducible early growth response protein 1; Krueppel-like factor 10; TIEG-1; EGR-alpha; KLF10; TIEG; GDNF-inducible factor; Transcription factor GIF; mGIF; KLF10_HUMAN.
    纯化方法HPLC
    研究领域

    Cancer > Growth factors > TGF

    Cancer > Signal transduction > Nuclear signaling > Nuclear hormone receptors > Estrogen

    Cardiovascular > Heart > Hypertrophy > Transcription factors

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > Krueppel like factor

    Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

    亚细胞定位Nucleus.
    翻译后修饰Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable).
    相似性Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.
    功能Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料KLF10 is a transcription factor that plays a role in the regulation of cell growth. It binds to the consensus sequence 5'-GGTGTG-3'. KLF10 plays a role in the response to TGFbeta (through the TGFbeta/Smad signalling pathway) and estrogen. In both cases, KLF10 induces or repressed gene transcription to enhance the TGFbeta/Smad signalling pathway, as well as other pathways, to regulate cell proliferation, differentiation and apoptosis. KLF10 has been shown to have a role in skeletal disease (osteopenia/osteoporosis), hypertrophic cardiomyopathy, and breast and prostate cancer.

     

     

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