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- bs-2643P
- 2025年10月16日
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500ug
| 产品编号 | bs-2643P |
| 英文名称 | KIR2DL4 Antibody Blocking Peptide |
| 中文名称 | NK细胞抑制性受体2DL4（CD158D）封闭多肽 |
| 英文别名 | Killer cell immunoglobulin-like receptor 2DL4; MHC class I NK cell receptor KIR103AS; KIR103; CD158d; CD158 antigen like family member D; CD158D; G9P; Killer cell immunoglobulin like receptor, two domains, long cytoplasmic tail, 4 ; Killer cell inhibitory receptor 103AS; KIR 103AS; NK cell receptor; natural killer cell inhibitory receptor; KI2L4_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Cell Type Markers > CD > NK Cells |
| 亚基 | Interacts with ARRB2. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 相似性 | Belongs to the immunoglobulin superfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) |
| 功能 | Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
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KIR2DL4 Antibody Blocking Peptide(bs-2643P)-500ug
￥880
