- ￥880
- Bioss
- bs-14275P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-14275P |
| 英文名称 | DENND5B Antibody Blocking Peptide |
| 中文名称 | DENND5B蛋白封闭多肽 |
| 英文别名 | DENN domain containing protein 5B; DENN MADD domain containing 5B; Dennd5b; DEN5B_HUMAN; Rab6IP1 like protein. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Membrane; Single-pass membrane protein. |
| 相似性 | Belongs to the RAB6IP1 family. Contains 1 dDENN domain. Contains 1 DENN domain. Contains 1 PLAT domain. Contains 2 RUN domains. Contains 1 uDENN domain. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | DENND5B is a 1,274 amino acid single-pass membrane protein containing a dDENN domain, a DENN domain, a PLAT domain, two RUN domains and an uDENN domain. Existing as four alternatively spliced isoforms, DENND5B is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a number of skeletal deformities, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. |
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DENND5B Antibody Blocking Peptide(bs-14275P)-500ug
￥880
