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- bs-14268P
- 2025年10月16日
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500ug
| 产品编号 | bs-14268P |
| 英文名称 | DENN Antibody Blocking Peptide |
| 中文名称 | 死亡结构域接头蛋白DENN封闭多肽 |
| 英文别名 | Differentially expressed in normal and neoplastic cells; FLJ35600; IG20; Insulinoma glucagonoma clone 20; KIAA0358; MADD; MADD_HUMAN; MAP kinase-activating death domain protein; Rab3 GDP/GTP exchange factor; RAB3GEP. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Receptors > Death receptors & ligands > FADD Cancer > Cell Death > Apoptosis > Receptors > Death receptors & ligands > TRADD Cancer > Invasion/microenvironment > Apoptosis > Death receptors & ligands > FADD Cancer > Invasion/microenvironment > Apoptosis > Death receptors & ligands > TRADD Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers |
| 亚细胞定位 | Membrane. |
| 组织特异性 | Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines. |
| 相似性 | Belongs to the MADD family. Contains 1 dDENN domain. Contains 1 death domain. Contains 1 DENN domain. Contains 1 uDENN domain. |
| 功能 | Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
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DENN Antibody Blocking Peptide(bs-14268P)-500ug
￥880
