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- 2025年10月16日
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500ug
| 产品编号 | bs-3102P |
| 英文名称 | Phospho-DOK2 (Tyr299) Antibody Blocking Peptide |
| 中文名称 | 磷酸化D酪氨酸激酶衰减蛋白2封闭多肽 |
| 英文别名 | DOK2 (Phospho-Tyr299); DOK2 (Phospho Tyr299); DOK2 (Phospho Y299); Docking protein 2 56kDa; Docking protein 2 antibody DOK 2; DOK R; Downstream of tyrosine kinase 2; p56(dok 2); p56dok 2; p56DOK; p56dok2; DOK2; DOK2_HUMAN; Downstream of tyrosine kinase 2; OTTHUMP00000161710; OTTHUMP00000224923; p56(dok 2); p56(dok-2). |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction Cancer > Signal transduction > Protein phosphorylation > Tyrosine kinases Signal Transduction > Adapters > Cytoplasmic Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > MAPK Pathway |
| 亚基 | Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. Interacts (via PH domain) with TEK/TIE2 (tyrosine phosphorylated). |
| 亚细胞定位 | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation. |
| 组织特异性 | Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. |
| 翻译后修饰 | On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. |
| 相似性 | Belongs to the DOK family. Type A subfamily.
Contains 1 IRS-type PTB domain. Contains 1 PH domain. |
| 功能 | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008] |
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Phospho-DOK2 (Tyr299) Antibody Blocking Peptide(bs-3102P)-500ug
￥1080
