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- bs-3098P
- 2025年10月16日
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500ug
| 产品编号 | bs-3098P |
| 英文名称 | Phospho-Connexin 43 (Ser368) Antibody Blocking Peptide |
| 中文名称 | 磷酸化Connexin 43蛋白封闭多肽 |
| 英文别名 | Connexin 43(phospho-Ser368); Connexin 43(phospho Ser368); Connexin 43(phospho S368); Connexin 43; Connexin43v Cx 43v CX43; DFNB38; Gap junction 43 kDa heart protein;Connexin-43; Gap junction alpha 1 protein; Gap junction protein alpha 1 43kDa (connexin 43); Gap junction protein alpha 1 43kDa; Gap junction protein alpha like; GJA 1; GJA1; GJA-1; GJAL; HGNC:4282; HGNC:8112; Oculodentodigital dysplasia; ODD; ODOD; SDTY3; Syndactyly type III; CXA1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment > Cell junction molecules Cardiovascular > Heart > Cardiac arrhythmias Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Gap Junctions |
| 亚基 | A connexon is composed of a hexamer of connexins. Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts with UBQLN4. Interacts with SGSM3. Interacts with KIAA1432/CIP150. Interacts with CNST and CSNK1D. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. |
| 组织特异性 | Expressed in the heart and fetal cochlea. |
| 翻译后修饰 | Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity. Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. |
| 相似性 | Belongs to the connexin family. Alpha-type (group II) subfamily. |
| 功能 | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neiGHBoring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. [provided by RefSeq]. |
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Phospho-Connexin 43 (Ser368) Antibody Blocking Peptide(bs-3098P)-500ug
￥1080
