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- Bioss
- bs-11764P
- 2025年10月16日
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500ug
| 产品编号 | bs-11764P |
| 英文名称 | OPA1 Antibody Blocking Peptide |
| 中文名称 | 视神经萎缩相关蛋白1封闭多肽 |
| 英文别名 | Dynamin like 120 kDa protein; Dynamin like 120 kDa protein, mitochondrial; Dynamin-like 120 kDa protein; Dynamin-like 120 kDa protein, form S1; FLJ12460; Juvenile kjer type optic atrophy; Juvenile kjer-type optic atrophy; KIAA0567; KJER type; Large GTP binding protein; largeG; MGM1; Mitochondrial dynamin like 120 kDa protein; Mitochondrial dynamin like GTPase; NPG; NTG; OAK; OPA 1; OPA1; OPA1 gene; OPA1_HUMAN; Optic atrophy 1 (autosomal dominant); OPTIC ATROPHY 1; Optic atrophy 1 gene protein; Optic atrophy 1 homolog (human); Optic atrophy protein 1; Optic atrophy protein 1 homolog. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Heart > Cardiac metabolism Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitophagy fission and fusion Neuroscience > Neurology process > Neurodegenerative disease Neuroscience > Sensory System > Visual system |
| 亚细胞定位 | Mitochondrion inner membrane. Mitochondrion intermembrane space. |
| 组织特异性 | Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues. |
| 翻译后修饰 | PARL-dependent proteolytic processing releases an antiapoptotic soluble form not required for mitochondrial fusion. |
| 相似性 | Belongs to the dynamin family. |
| 功能 | Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | OPA1 is a 120kDa protein belonging to the dynamin family. The OPA1 gene has been localized to 3q29. The gene is targeted to mitochondria and is involved in mitochondrial biogenesis. Defects in OPA1 are a cause of optic atrophy type 1. OPA1 is mostly expressed in retina but can also be expressed in brain, testis, heart and skeletal muscle. |
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OPA1 Antibody Blocking Peptide(bs-11764P)-500ug
￥880
