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- Bioss
- bs-11752P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11752P |
| 英文名称 | REEP1 Antibody Blocking Peptide |
| 中文名称 | 受体辅助蛋白1封闭多肽 |
| 英文别名 | C2orf23; Chromosome 2 open reading frame 23; FLJ13110; Receptor accessory protein 1; Receptor expression-enhancing protein 1; Reep1; REEP1_HUMAN; SPG31. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease Neuroscience > Sensory System > Olfactory system |
| 亚基 | Interacts with SPAST and ATL1; it preferentiallyinteracts with SPAST isoform 1. Interacts (via C-terminus) withmicrotubules. Interacts with odorant receptor proteins |
| 亚细胞定位 | Membrane. Mitochondrion membrane; Multi-passmembrane protein. Endoplasmic reticulum. |
| 翻译后修饰 | Belongs to the DP1 family. |
| 相似性 | Belongs to the DP1 family. |
| 功能 | May enhance the cell surface expression of odorant receptors. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Transport of G protein-coupled receptors (GPCRs) to the cell surface membrane is critical for receptor-ligand recognition. Mammalian GPCR odorant receptors (ORs), when heterologously expressed in cells, are poorly expressed on the cell surface. REEP1 (receptor expression-enhancing protein 1), is a 201 amino acid multi-pass mitochondrion membrane protein that belongs to the DP1 family. REEP1 interacts with odorant receptor proteins and may enhance the cell surface expression of odorant receptors. Mutations in the REEP1 gene are the third most common cause of hereditary spastic paraplegia (HSP) after spastin and atlastin gene mutations. Mutations in the REEP1 gene also cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. The REEP1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana and rice, and maps to human chromosome 2p11.2. |
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REEP1 Antibody Blocking Peptide(bs-11752P)-500ug
￥880
