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- Bioss
- bs-2603P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-2603P |
| 英文名称 | Il12rb1 Antibody Blocking Peptide |
| 中文名称 | 白细胞介素-12受体β1封闭多肽 |
| 英文别名 | Interleukin-12 receptor subunit beta-1; IL12RB1; IL-12RB1; CD212; IL-12R-BETA1; IL12RB; MGC34454; IL-12 receptor beta component; interleukin-12 receptor beta-1 chain; IL-12RB1; IL-12R-beta-1; IL-12R subunit beta-1; IL-12 receptor subunit beta-1; I12R1_MOUSE. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > Cytokines > Interleukins |
| 亚基 | Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 相似性 | Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 5 fibronectin type-III domains. |
| 功能 | Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]. |
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Il12rb1 Antibody Blocking Peptide(bs-2603P)-500ug
￥880
