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- bs-13039P
- 2025年10月16日
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500ug
| 产品编号 | bs-13039P |
| 英文名称 | phospho-DNM1 (Ser774) Antibody Blocking Peptide |
| 中文名称 | 磷酸化酶动力蛋白1封闭多肽 |
| 英文别名 | Dynamin 1 (phospho S774); Dynamin 1 (phospho Ser774); p-Dynamin 1 (S774); p-Dynamin 1 (Ser774); B dynamin; D100; DNM 1; DNM; DNM1; DYN1_HUMAN; Dynamin; Dynamin-1; Dynamin1. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation |
| 亚基 | Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). |
| 亚细胞定位 | Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated. |
| 相似性 | Belongs to the dynamin family. Contains 1 GED domain. Contains 1 PH domain. |
| 功能 | Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (2–5). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (2–5). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5). Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis. |
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phospho-DNM1 (Ser774) Antibody Blocking Peptide(bs-13039P)-500ug
￥1080
