- ￥1080
- Bioss
- bs-3067P
- 2025年10月16日
企业认证
相关产品推荐更多 >
CLCN5 Antibody Blocking Peptide(bs-10307P)-500ug
￥880
Phospho-CFL1 (Ser3) Antibody Blocking Peptide(bs-3099P)-500ug
￥1080PD-1 Antibody Blocking Peptide(bs-1867P)-500ug
￥880FOXM1 Antibody Blocking Peptide(bs-2687P)-500ug
￥880Recombinant SARS-Cov-2 Spike S1 protein, His & Avi (HEK293)(bs-46004P)-100ug/500ug
￥3980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-3067P |
| 英文名称 | Phospho-Bcr (Tyr177) Antibody Blocking Peptide |
| 中文名称 | 磷酸化T淋巴细胞受体封闭多肽 |
| 英文别名 | Bcr (phospho Y177); Bcr(Phospho-Tyr177); ALL; BCR 1; BCR/ABL FUSION GENE INCLUDED; BCR/FGFR1 FUSION GENE INCLUDED; BCR/PDGFRA FUSION GENE INCLUDED; BCR1; breakpoint cluster region; CML; PHL; BCR_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction > Protein phosphorylation > Serine/threonine kinases Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Ras Family |
| 亚基 | Homotetramer. Interacts with PDZK1. May interact with CCPG1. Interacts with FES/FPS, ABL1, PIK3R1 and GRB2. Interacts with HCK. |
| 亚细胞定位 | Cytoplasm. |
| 翻译后修饰 | Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2. |
| 相似性 | Contains 1 C2 domain. Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 Rho-GAP domain. |
| 功能 | GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Phospho-Bcr (Tyr177) Antibody Blocking Peptide(bs-3067P)-500ug
￥1080
