- ￥800
- Bioss
- bs-6327P
- 2025年10月16日
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500ug
| 产品编号 | bs-6327P |
| 英文名称 | FLG Antibody Blocking Peptide |
| 中文名称 | 丝聚蛋白/中间丝相关蛋白封闭多肽 |
| 英文别名 | FLG; Epidermal filaggrin; Filaggrin precursor; Fillagrin; Profilaggrin; FILA_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Intermediate Filaments > Class I > Cytokeratins Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > Cytokeratin Tags & Cell Markers > Cell Type Markers > Epi / Endo-thelial |
| 组织特异性 | Keratohyalin granules. |
| 翻译后修饰 | Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate.
Undergoes deimination of some arginine residues (citrullination). |
| 相似性 | Belongs to the S100-fused protein family. Contains 2 EF-hand domains. Contains 23 filaggrin repeats. |
| 功能 | Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]. |
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FLG Antibody Blocking Peptide(bs-6327P)-500ug
￥800
