phospho-Cilk1 (Tyr159) Antibody Blocking Peptide(bs-15535P)-500ug

phospho-Cilk1 (Tyr159) Antibod

y Blocking Peptide(bs-15535P)-500ug
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  • bs-15535P
  • 2025年10月16日
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      500ug

    产品编号bs-15535P
    英文名称phospho-Cilk1 (Tyr159) Antibody Blocking Peptide
    中文名称丝氨酸/苏氨酸蛋白激酶ICK封闭多肽
    英文别名ICK (phospho Y159); p-ICK (phospho Y159); ICK(Tyr159); 2210420N10Rik; AI848300; ECO; ICK_HUMAN; Heart serine threonine protein kinase; hICK; Intestinal cell (MAK like) kinase; Intestinal cell kinase; KIAA0936; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MAK related kinase; MGC46090; mICK; MRK; OTTMUSP00000041856; OTTMUSP00000041857; Serine/threonine-protein kinase ICK; Serine/threonine protein kinase ICK.
    纯化方法HPLC
    亚细胞定位Nucleus. Cytoplasm, cytosol. Note=Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). Cytosolic localization was shown in rat embryonic cardiomyocytes by immunostaining (PubMed:8570168).
    组织特异性Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
    翻译后修饰Autophosphorylated on serine and threonine residues. May play a role in enzyme activation.
    相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
    功能May play a key role in the development of multiple organ systems and particularly in cardiac development.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.

     

     

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