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- 详细信息
- 技术资料
- 规格:
500ug
| 产品编号 | bs-13002P |
| 英文名称 | DIAPH2 Antibody Blocking Peptide |
| 中文名称 | DIAPH2蛋白封闭多肽 |
| 英文别名 | Dia 2; DIA; Dia drome; Dia2; Diap 2; Diap2; DIAP2_HUMAN; DIAPH 2; DIAPH2; Diaphanous 2; Diaphanous homolog 2 (Drosophila); Diaphanous homolog 2; Diaphanous related formin 2; Diaphanous-related formin-2; Diaphanous2; Diaphorase 2; Diaphorase2; DRF 2; DRF2; FLJ11167; OTTHUMP00000024270; OTTHUMP00000024271; OTTHUMP00000062171; POF 2; POF; POF2; Protein diaphanous homolog 2. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Binding Proteins Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation |
| 亚基 | Isoform 3 interacts with RHOD in the GTP-bound form. |
| 亚细胞定位 | Cytoplasm > cytosol. Early endosome. Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes. |
| 组织特异性 | Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes. |
| 相似性 | Belongs to the formin homology family. Diaphanous subfamily. Contains 1 DAD (diaphanous autoregulatory) domain. Contains 1 FH1 (formin homology 1) domain. Contains 1 FH2 (formin homology 2) domain. Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. |
| 功能 | Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
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DIAPH2 Antibody Blocking Peptide(bs-13002P)-500ug
¥880





