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- Bioss
- bs-13005P
- 2025年10月16日
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- 详细信息
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- 规格：
500ug
| 产品编号 | bs-13005P |
| 英文名称 | DKK2 Antibody Blocking Peptide |
| 中文名称 | DKK2封闭多肽 |
| 英文别名 | Dickkopf 2; Dickkopf gene 2; Dickkopf homolog 2; Dickkopf related protein 2; Dickkopf-2; Dickkopf-related protein 2; Dickkopf2; DKK 2; Dkk-2; DKK2_HUMAN; hDkk 2; hDkk-2; hDkk2. |
| 纯化方法 | HPLC |
| 研究领域 | Stem Cells > Signaling Pathways > Wnt > Secreted |
| 亚基 | Interacts with LRP5 and LRP6. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Expressed in heart, brain, skeletal muscle and lung. |
| 翻译后修饰 | May be proteolytically processed by a furin-like protease. |
| 相似性 | Belongs to the dickkopf family. |
| 功能 | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] |
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DKK2 Antibody Blocking Peptide(bs-13005P)-500ug
￥880
