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- Bioss
- bs-2544P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-2544P |
| 英文名称 | SLAMF7/CD319R Antibody Blocking Peptide |
| 中文名称 | SLAMF7封闭多肽 |
| 英文别名 | 19A; 19A24 protein; CD2 like receptor activating cytotoxic cells; CD2 subset 1; CD 319; CD319; CD319 antigen; CRACC; CS1; Membrane protein FOAP 12; Novel Ly9; Novel LY9 (lymphocyte antigen 9) like protein; Protein 19A; SLAM family member 7; SLAMF 7; SLAMF7. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > NK Cells |
| 亚基 | Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro). |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Isoform 3 is expressed at much lower level than isoform 1 |
| 相似性 | Contains 1 Ig-like C2-type (immunoglobulin-like) domain. |
| 功能 | Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion.
Isoform 3 does not mediate any NK cell activation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms. |
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SLAMF7/CD319R Antibody Blocking Peptide(bs-2544P)-500ug
￥880
