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- bs-2543P
- 2025年10月16日
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500ug
| 产品编号 | bs-2543P |
| 英文名称 | CLEC1B Antibody Blocking Peptide |
| 中文名称 | C型凝集素结构域家族1成员B封闭多肽 |
| 英文别名 | C-type lectin domain family 1 member B; 1810061I13Rik; C type lectin domain family 1 member B; C type lectin like receptor 2; C-type lectin domain family 1, member B; C-type lectin-like receptor-2; CLEC 2; CLEC 2B; CLEC-2; CLEC2; CLEC2B; PRO1384; QDED721; CLC1B_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Cell Type Markers > CD > Myeloid Cells Immunology > Cell Type Markers > CD > NK Cells |
| 亚基 | Homodimer. |
| 亚细胞定位 | Membrane; Single-pass type II membrane protein (Probable). |
| 组织特异性 | Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. |
| 翻译后修饰 | Glycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding. |
| 相似性 | Contains 1 C-type lectin domain. |
| 功能 | Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] |
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CLEC1B Antibody Blocking Peptide(bs-2543P)-500ug
￥880
