CTF1 Antibody Blocking Peptide(bs-2534P)-500ug

CTF1 Antibody Blocking Peptide

(bs-2534P)-500ug
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  • ¥880
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  • bs-2534P
  • 2025年10月16日
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      500ug

    产品编号bs-2534P
    英文名称CTF1 Antibody Blocking Peptide
    中文名称心肌营养素1封闭多肽
    英文别名cardiotrophin-1; Cardiophin1; Cardiotrophin 1; Cardiotrophin I; CardiotrophinI; CT1; CTF 1; CTF1; CTF1_HUMAN.
    纯化方法HPLC
    亚细胞定位Secreted.
    组织特异性Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.
    相似性Belongs to the IL-6 superfamily.
    功能Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Cardiotrophin-1 (CT-1), a cardiac hypertrophic factor, is a 21.5 kDa protein member of the IL-6 cytokine family. CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF kappa B DNA -binding activities. CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine.

     

     

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