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- bs-2973P
- 2025年10月16日
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500ug
| 产品编号 | bs-2973P |
| 英文名称 | SMAD1 + SMAD5 Antibody Blocking Peptide |
| 中文名称 | 细胞信号转导分子SMAD1 + SMAD5封闭多肽 |
| 英文别名 | Dwfc; hSmad 5; hSmad5; JV5 1; JV5-1; MAD homolog 5; MAD mothers against decapentaplegic homolog 5; MAD, mothers against decapentaplegic homolog 5; MADH 5; MADH5; Mothers against decapentaplegic homolog 5; Mothers against DPP homolog 5; MusMLP; SMA and MAD related protein 5; SMAD 5; SMAD family member 5; SMAD mothers against DPP homolog 5; Smad5; SMAD5_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Organogenesis > Gut development > Liver development Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > SMADs Signal Transduction > Signaling Pathway > Nuclear Signaling > SMADs Stem Cells > Signaling Pathways > TGF beta > Cytoplasmic |
| 亚基 | May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1. |
| 亚细胞定位 | Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. |
| 组织特异性 | Ubiquitous. |
| 翻译后修饰 | Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. |
| 相似性 | Belongs to the dwarfin/SMAD family.
Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology 2) domain. |
| 功能 | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
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SMAD1 + SMAD5 Antibody Blocking Peptide(bs-2973P)-500ug
￥880
