- ￥880
- Bioss
- bs-11738P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11738P |
| 英文名称 | Nmnat1 Antibody Blocking Peptide |
| 中文名称 | 烟酰胺核苷酸腺苷转移酶1封闭多肽 |
| 英文别名 | NaMN adenylyltransferase 1; Nicotinamide mononucleotide adenylyltransferase 1; nicotinamide nucleotide adenylyltransferase 1; nicotinate nucleotide adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NMNA1_HUMAN; Nmnat 1; Nmnat1; Nmnat-1; OTTHUMP00000001731; OTTHUMP00000001732; OTTHUMP00000035892; PNAT 1; PNAT1; pyridine nucleotide adenylyltransferase 1. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > ADP-ribosylation Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism Metabolism > Types of disease > Cancer Neuroscience > Neurology process > Neurodegenerative disease Signal Transduction > Metabolism > Energy Metabolism |
| 亚基 | Homohexamer. Interacts with ADPRT/PARP1. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Widely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain. |
| 相似性 | Belongs to the eukaryotic NMN adenylyltransferase family. |
| 功能 | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nicotinamide adenine dinucleotide (NMNAT) is an essential cofactor involved in fundamental processes in cell metabolism. NMNAT plays a key role in NAD(+) biosynthesis, catalysing the condensation of nicotinamide mononucleotide and ATP, and yielding NAD(+) and pyrophosphate. NMNAT appears to be a substrate of nuclear kinases and contains at least three potential phosphorylation sites. The interaction of NMNAT with nuclear proteins is likely to be modulated by phosphorylation. NMNAT is widely expressed with highest levels in skeletal muscle, heart, liver and kidney. |
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Nmnat1 Antibody Blocking Peptide(bs-11738P)-500ug
￥880
