- ￥580 - 5680
- Bioss
- bs-42009P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
100ug/500ug/20ug
| 规格： | 100ug | 产品价格： | ￥1880.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥5680.0 |
| 规格： | 20ug | 产品价格： | ￥580.0 |
| 产品编号 | bs-42009P |
| 英文名称 | Recombinant human FZD3 protein, His |
| 中文名称 | 重组人卷曲蛋白3 |
| 英文别名 | Frizzled 3; Frizzled 3 seven transmembrane spanning receptor; Frizzled family receptor 3; Frizzled homolog 3 (Drosophila); Frizzled homolog 3; Frizzled-3; Frizzled3; Fz 3; Fz-3; Fz3; FZD 3; Fzd3; FZD3_HUMAN; hFz 3; hFz3; Recombinant human FZD3 protein, His |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 21.4 |
| 实际分子量 | 30 kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | 8 M Urea (pH=9.0). |
| 研究领域 | Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR Stem Cells > Signaling Pathways > Wnt > Surface Molecules |
| 亚基 | Interacts with VANGL2. |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis. |
| 翻译后修饰 | Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
| 相似性 | Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain. |
| 功能 | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010] |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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Recombinant human FZD3 protein, His(bs-42009P)-100ug/500ug/20ug
￥580 - 5680
