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- bs-2960P
- 2025年10月16日
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500ug
| 产品编号 | bs-2960P |
| 英文名称 | KCNJ1 Antibody Blocking Peptide |
| 中文名称 | ATP调节钾离子通道ROM K封闭多肽 |
| 英文别名 | ROM K; ROM-K; inwardly rectifying subfamily J member 1; ATP regulated potassium channel ROM K; ATP sensitive inward rectifier potassium channel 1; ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; Inward rectifier K(+) channel Kir1.1; inwardly rectifying K+ channel; IRK1_HUMAN; KCNJ 1; KCNJ; Kcnj1; Kir 1.1; Kir1.1; Potassium channel; Potassium channel inwardly rectifying subfamily J member 1; potassium inwardly-rectifying channel J1; ROMK 1; ROMK 2; ROMK; ROMK1; ROMK2. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Metabolism > Plasma Membrane > Channels Signal Transduction > Signaling Pathway > Calcium Signaling |
| 亚基 | Interacts with SGK1 and SLC9A3R2/NHERF2. |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 组织特异性 | In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. |
| 翻译后修饰 | Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. |
| 相似性 | Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily. |
| 功能 | In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
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KCNJ1 Antibody Blocking Peptide(bs-2960P)-500ug
￥880
