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- bs-2952P
- 2025年10月16日
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500ug
| 产品编号 | bs-2952P |
| 英文名称 | NFATC3 Antibody Blocking Peptide |
| 中文名称 | T细胞转录因子NFAT4封闭多肽 |
| 英文别名 | C80703; cytoplasmic 3; D8Ertd281e; NF AT4; NF ATc3; NF-AT4; NF-ATc3; NFAC3_HUMAN; NFATc3; NFATx; Nuclear factor of activated T cells, cytoplasmic 3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3; Nuclear factor of activated T-cells; T cell transcription factor NFAT4; T-cell transcription factor NFAT4. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > NFATs Signal Transduction > Signaling Pathway > Nuclear Signaling > NFATS |
| 亚基 | Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. |
| 组织特异性 | Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle. |
| 翻译后修饰 | Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin. |
| 相似性 | Contains 1 RHD (Rel-like) domain. |
| 功能 | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. |
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NFATC3 Antibody Blocking Peptide(bs-2952P)-500ug
￥880
