- ￥880
- Bioss
- bs-2948P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-2948P |
| 英文名称 | ABCE1 Antibody Blocking Peptide |
| 中文名称 | 核糖核酸酶L抑制蛋白封闭多肽 |
| 英文别名 | 2' 5' oligoadenylate binding protein; 2''-5''-oligoadenylate-binding protein; 2'5' oligoadenylate binding protein; ABC 38; ABC38; ABCE 1; ABCE1; ABCE1_HUMAN; ATP binding cassette sub family E (OABP) member 1; ATP binding cassette sub family E member 1; ATP-binding cassette sub-family E member 1; HuHP 68; HuHP68; OABP; Ribonuclease 4 Inhibitor; Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitor; Ribonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitor; Ribonuclease L inhibitor; RLI; RNase L Inhibitor; RNASEL1; RNASELI; RNS 4I; RNS4I. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Immune System Diseases > Antiviral Signaling Signal Transduction > Adapters > Transmembrane Signal Transduction > Metabolism > Plasma Membrane > ATPases Signal Transduction > Protein Trafficking > Chaperones > Other Chaperones |
| 亚基 | Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL. Associates with HIV-1 Vif and HIV-1, HIV-2 and SIV Gag proteins. |
| 亚细胞定位 | Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane. |
| 相似性 | Belongs to the ABC transporter superfamily. ABCE family. Contains 2 4Fe-4S ferredoxin-type domains. Contains 2 ABC transporter domains. |
| 功能 | Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ABCE1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. It is alternatively referred to as the RNase L inhibitor as it functions to block the activity of ribonuclease L(referenced from entrez gene). |
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ABCE1 Antibody Blocking Peptide(bs-2948P)-500ug
￥880
