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- bs-11680P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-11680P |
| 英文名称 | BACE2 Antibody Blocking Peptide |
| 中文名称 | β淀粉样前体蛋白裂解酶2封闭多肽 |
| 英文别名 | ALP 56; ALP-56; ALP56; ALP56; Asp 1; ASP1; ASP1; ASP21; Aspartic Like Protease 56kDa; Aspartic Like Protease 56kDa; Aspartic-like protease 56 kDa; Aspartyl protease 1; Aspartyl protease 1; BACE 2; BACE 2; Bace2; BACE2_HUMAN; Beta Secretase 2; Beta Secretase 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta-secretase 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; Down region aspartic protease; Downs Syndrome Region Aspartic Protease; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin 1; Memapsin1; Memapsin-1; Membrane associated aspartic protease 1; Membrane-associated aspartic protease 1; Theta-secretase. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Aspartic protease > BACEs Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease > Proteases |
| 亚基 | Monomer. Interacts ith RTN3 and RTN4. |
| 亚细胞定位 | Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface. |
| 组织特异性 | Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. |
| 翻译后修饰 | Undergoes autoproteolytic cleavage. Glycosylated. |
| 相似性 | Belongs to the peptidase A1 family. |
| 功能 | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. |
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BACE2 Antibody Blocking Peptide(bs-11680P)-500ug
￥880
