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- Bioss
- bs-2514P
- 2025年10月16日
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500ug
| 产品编号 | bs-2514P |
| 英文名称 | CCR5 Antibody Blocking Peptide |
| 中文名称 | 细胞表面趋化因子受体5封闭多肽 |
| 英文别名 | C-C chemokine receptor 5; CCR5; CC-CKR-5;CCR-5; CCCKR5; CD195; CD 195; CKR-5; CKR5; CMKBR5; FLJ78003; IDDM22; AM4-7; C C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; CC Chemokine Receptor Type 5; CCR5 chemokine (C C motif) receptor 5; Chemokine receptor CCR5; CHEMR13; HIV 1 Fusion Coreceptor; HIV1 fusion coreceptor; IDDM22; MIP-1 alpha receptor; CCR5_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction > G protein signaling > GPCR Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment > Chemokines Immunology > Immune System Diseases > Antiviral Signaling > HIV-related Immunology > Innate Immunity > Chemokines > Beta Chemokine Rec. (CCR) Immunology > Innate Immunity > Macrophage / Inflamm. Microbiology > Interspecies Interaction > Host Virus Interaction Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚基 | Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Interacts with human cytomegalovirus/HHV-5 protein UL78. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]. |
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CCR5 Antibody Blocking Peptide(bs-2514P)-500ug
￥880
