- ￥480 - 4880
- Bioss
- bs-41156P
- 2025年10月16日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 规格：
100ug/500ug/20ug
| 规格： | 100ug | 产品价格： | ￥1280.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥4880.0 |
| 规格： | 20ug | 产品价格： | ￥480.0 |
| 产品编号 | bs-41156P |
| 英文名称 | Recombinant human bFGF protein, His |
| 中文名称 | 重组人碱性成纤维生长因子 |
| 英文别名 | Basic fibroblast growth factor; FGF basic; FGF-basic; BFGF; FGF-2; FGF B; FGF2; FGF2 basic; FGFB; Fibroblast growth factor 2 (basic); HBGF 2; HBGF-2; HBGF2; HBGH 2; HBGH2; Heparin binding growth factor 2 precursor; Prostatropin; FGF2_HUMAN; Recombinant human bFGF protein, His |
| 性状 | Lyophilized or Liqui |
| 纯化方法 | AC |
| 理论分子量 | 17 |
| 实际分子量 | 26 kDa |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | 10mM Tris-HCl 8M Urea with 500mM NaCl 300mM imidazole and 10% Glycerol. |
| 研究领域 | Cancer > Growth factors > FGF Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors Cardiovascular > Angiogenesis > Growth Factors > FGF > FGF Developmental Biology > Organogenesis > Excretory system development > Kidney development Neuroscience > Neurology process > Neurogenesis Signal Transduction > Growth Factors/Hormones > FGF Stem Cells > Neural Stem Cells > Extracellular |
| 亚基 | Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. |
| 亚细胞定位 | Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57. |
| 组织特异性 | Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue. |
| 翻译后修饰 | Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing. |
| 相似性 | Belongs to the heparin-binding growth factors family. |
| 功能 | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]. |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Recombinant human bFGF protein, His(bs-41156P)-100ug/500ug/20ug
￥480 - 4880
