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- bs-15506P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-15506P |
| 英文名称 | TRPV6 Antibody Blocking Peptide |
| 中文名称 | 钙转运蛋白1封闭多肽 |
| 英文别名 | ABP/ZF; ABPZF; Alu binding protein with zinc finger domain; Calcium channel CaT1; Calcium transport protein 1; CaT L; CaT Like; CaT-L; CaT-like; CaT1; ecac; ECaC2; Epithelial apical membrane calcium transporter/channel CaT1; Epithelial calcium channel 2; Epithelial calcium channel; HSA277909; LP6728; MGC162545; NUDC; Transient receptor potential cation channel subfamily V member 6; TrpV6; TRPV6_HUMAN; ZFAB. |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Vitamins / minerals Signal Transduction > Metabolism > Vitamins / Minerals Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Channels |
| 亚基 | Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY (By similarity). Interacts with calmodulin. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein (By similarity). |
| 组织特异性 | Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia. |
| 翻译后修饰 | Glycosylated (By similarity). Phosphorylation at Tyr-161 by SRC leads to an increased calcium influx through the channel. Probably dephosphorylated at this site by PTPN1 (By similarity). Phosphorylation by PRKCA at the calmodulin binding site delays channel inactivation. |
| 相似性 | Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily. Contains 6 ANK repeats. |
| 功能 | Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the vanilloid family of transient receptor potential (TRP) calcium channel proteins. Proteins in this TRP family have an N-terminal ankyrin repeat domain, which is required for channel assembly and regulation. [provided by RefSeq, Nov 2011]. |
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TRPV6 Antibody Blocking Peptide(bs-15506P)-500ug
￥880
