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- bs-12982P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-12982P |
| 英文名称 | DAPP1 Antibody Blocking Peptide |
| 中文名称 | B淋巴细胞衔接分子DAPP1封闭多肽 |
| 英文别名 | B cell adapter molecule of 32 kDa; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa; BAM32; DAPP1; DAPP1_HUMAN; DKFZp667E0716; Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; Dual adaptor of phosphotyrosine and 3 phosphoinositides; hDAPP1. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Adaptive Immunity > B Cells > Non-CD Signal Transduction > Adapters > Cytoplasmic |
| 亚基 | Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2. |
| 亚细胞定位 | Cytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation. |
| 组织特异性 | Detected in heart and liver, and at low levels in skeletal muscle, kidney and pancreas. |
| 翻译后修饰 | Phosphorylated on tyrosine residues. |
| 相似性 | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| 功能 | May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | DHRS1 (dehydrogenase/reductase (SDR family) member 1), also known as SDR19C1, is a 313 amino acid protein that belongs to the short-chain dehydrogenases/reductases (SDR) family and likely functions as an oxidoreductase. Abundantly expressed in heart and liver, DHRS1 contains an SDR motif and is encoded by a gene that maps to human chromosome 14q12. Human chromosome 14 houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. |
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DAPP1 Antibody Blocking Peptide(bs-12982P)-500ug
￥880
