- ￥880
- Bioss
- bs-2918P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-2918P |
| 英文名称 | RAP1GAP Antibody Blocking Peptide |
| 中文名称 | RAP1GAP酶激活蛋白封闭多肽 |
| 英文别名 | Rap1 GTPase activating protein 1; RAP1 GTPase activating protein; RAP1GA1; Rap1ga1 protein; RAP1GAP1; RAP1GAPII; RAPGAP; KIAA0474; RPGP1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Tumor Suppressors Signal Transduction > Second Messenger > Nucleotide Messenger > GTP |
| 亚基 | Homodimer and heterodimer with RAP1B. |
| 亚细胞定位 | Golgi apparatus membrane; Peripheral membrane protein. |
| 组织特异性 | Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues. |
| 相似性 | Contains 1 GoLoco domain.
Contains 1 Rap-GAP domain. |
| 功能 | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | RAP1GAP, an 85/95kDa protein, is a member of a family of GAPs specific for Rap1. Though to be an important tumor suppressor, Rap1GAP has no sequence homology with other GAPs such as RasGAP, RanGAP and RhoGAP. Purified as a cytosolic and membrane-bound protein, both isoforms consist of two monomers each contain a dimerization and a catalytic domain. Mutations in the GAP domain of the tumor suppressor tuberin, can cause benign tumor phenotype tuberous sclerosis. There are 2 isoforms produced by alternative splicing. |
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RAP1GAP Antibody Blocking Peptide(bs-2918P)-500ug
￥880
