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- bs-2893P
- 2025年10月16日
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500ug
| 产品编号 | bs-2893P |
| 英文名称 | HDAC10 Antibody Blocking Peptide |
| 中文名称 | 组蛋白去乙酰化酶10封闭多肽 |
| 英文别名 | HD 10; HD10; HDAC 10; Histone deacetylase 10; MGC149722; OTTHUMP00000028555; DKFZP761B039; HDA10_HUMAN; Histone deacetylase 10; HD10. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HDACs > Class I Stem Cells > Signaling Pathways > Wnt > HDACs |
| 亚基 | Interacts with HDAC2, HDAC3 and NCOR2. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Excluded from the nucleoli. |
| 组织特异性 | Ubiquitous. High expression in liver, spleen, pancreas and kidney. |
| 相似性 | Belongs to the histone deacetylase family. HD type 2 subfamily. |
| 功能 | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The enzymes responsible for the reversible acetylation/ deacetylation process of histones are histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. HATs act as transcriptional coactivators and HDACs are part of transcriptional corepressor complexes. Mammalian HDACs can be divided into three classes according to sequence homology. Class I consists of the yeast Rpd3 like proteins HDAC1, HDAC2, HDAC3, and HDAC8. Class II consists of the yeast Hda1 like proteins HDAC10, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10. Class III comprises the yeast Sir2 like proteins. Whereas class I HDACs are ubiquitously expressed, most class II HDACs are tissue specific. HDAC10 is similar to HDAC6, both containing a unique putative second catalytic domain not found in other HDACs. However, this domain is not functional in HDAC10. The deacetylase activity of class II HDACs is regulated by subcellular localization. HDAC10 was localized to both the nucleus and cytoplasm. HDAC10 can deacetylate histones, repress transcription, and interact with HDAC3. |
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HDAC10 Antibody Blocking Peptide(bs-2893P)-500ug
￥880
