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- bs-25044P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-25044P |
| 英文名称 | PAWR Antibody Blocking Peptide |
| 中文名称 | 前列腺细胞凋亡反应蛋白4封闭多肽 |
| 英文别名 | 2310001G03Rik ; PAR 4 ; PAR-4 ; Pawr ; PAWR_HUMAN ; PRKC Apoptosis WT1 Regulator ; PRKC apoptosis WT1 regulator protein ; Prostate apoptosis response 4 protein ; Prostate apoptosis response protein 4 ; prostate apoptosis response protein PAR-4 ; Transcriptional repressor Par-4-like protein PAWR ; Transcriptional repressor PAR4 ; WT1 Interacting Protein . |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. |
| 组织特异性 | Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. |
| 翻译后修饰 | Preferentially phosphorylated at the Thr-163 by PKC in cancer cells. |
| 功能 | Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017] |
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PAWR Antibody Blocking Peptide(bs-25044P)-500ug
￥880
