- ￥880
- Bioss
- bs-21370P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-21370P |
| 英文名称 | ULBP2/N2DL2 Antibody Blocking Peptide |
| 中文名称 | UL16结合蛋白2封闭多肽 |
| 英文别名 | ALCAN alpha; N2DL 2; N2DL2; NKG2D ligand 2; NKG2D ligand 2 precursor; NKG2DL2; RAET1H; Retinoic acid early transcript 1 H; Retinoic acid early transcript 1H; UL16 binding protein; N2DL2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > NK Cells Immunology > Innate Immunity > TLR Signaling |
| 亚细胞定位 | Cell membrane; Lipid-anchor, GPI-anchor. |
| 组织特异性 | Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. |
| 相似性 | Belongs to the MHC class I family. |
| 功能 | Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ULBP2 is a human ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. The interaction with UL16 blocks the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. ULBP2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. |
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ULBP2/N2DL2 Antibody Blocking Peptide(bs-21370P)-500ug
￥880
