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- bs-15498P
- 2025年10月16日
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500ug
| 产品编号 | bs-15498P |
| 英文名称 | CDH23 Antibody Blocking Peptide |
| 中文名称 | 钙粘蛋白23封闭多肽 |
| 英文别名 | Cadherin like 23; Age related hearing loss 1; Ahl 1; Ahl; Ahl1; Bob; Bobby; Bus; Bustling; Cadherin 23; Cadherin23; Cadherin-23; CDH 23; Mdfw; Modifier of deaf waddler; nmf112; nmf181; nmf252; Otocadherin; USH 1D; USH1 D; USH1D; Waltzer; CAD23_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Sensory System > Auditory system Neuroscience > Sensory System > Visual system Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Cadherins |
| 亚基 | Interacts with PCDH15. Interacts with USH1C and USH1G. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 组织特异性 | Particularly strong expression in the retina. Found also in the cochlea. |
| 相似性 | Contains 27 cadherin domains. |
| 功能 | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]. |
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CDH23 Antibody Blocking Peptide(bs-15498P)-500ug
￥880
