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500ug
| 产品编号 | bs-15492P |
| 英文名称 | LOX Antibody Blocking Peptide |
| 中文名称 | 蛋白赖氨酸-6-氧化酶封闭多肽 |
| 英文别名 | lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Extracellular matrix Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment Cardiovascular > Vasculature > Endothelium Cardiovascular > Vasculature > Smooth muscle cell (SMC) > Extracellular matrix Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > Other Enzymes |
| 亚细胞定位 | Secreted; extracellular space |
| 组织特异性 | Heart, placenta, skeletal muscle, kidney, lung and pancreas. |
| 翻译后修饰 | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytically activated by BMP1 (By similarity). |
| 相似性 | Belongs to the lysyl oxidase family. |
| 功能 | Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016] |
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LOX Antibody Blocking Peptide(bs-15492P)-500ug
¥880







