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- bs-15487P
- 2025年10月16日
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500ug
| 产品编号 | bs-15487P |
| 英文名称 | P4HTM Antibody Blocking Peptide |
| 中文名称 | 缺氧诱导因子脯氨酰羟化酶4封闭多肽 |
| 英文别名 | PHD4/prolyl hydroxylase; EGLN4; FLJ20262; HIF prolyl hydroxylase PH4; HIF-PH4; HIF-prolyl hydroxylase 4; HIFPH4; HPH-4; Hypoxia inducible factor prolyl 4 hydroxylase; Hypoxia inducible factor prolyl hydroxylase; Hypoxia-inducible factor prolyl hydroxylase 4; P4H TM; P4H with transmembrane domain; P4H-TM; P4htm; P4HTM_HUMAN; PH 4; PH4; PHD4; Proline 4 hydroxylase; Prolyl 4 hydroxylase transmembrane (endoplasmic reticulum); Prolyl hydroxlase domain containing 4; Transmembrane prolyl 4-hydroxylase. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > Hypoxia > Hydroxylases Cardiovascular > Hypoxia > Prolyl Hydroxylase Epigenetics and Nuclear Signaling > Cardiovascular/Immune > Hypoxia > Prolyl hydroxylase |
| 亚基 | Homodimer. |
| 亚细胞定位 | Endoplasmic reticulum membrane; Single-pass type II membrane protein. |
| 组织特异性 | Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. |
| 翻译后修饰 | Glycosylated. |
| 相似性 | Contains 2 EF-hand domains.
Contains 1 Fe2OG dioxygenase domain. |
| 功能 | Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. |
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P4HTM Antibody Blocking Peptide(bs-15487P)-500ug
￥880
