- ￥880
- Bioss
- bs-15488P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-15488P |
| 英文名称 | HIG2 Antibody Blocking Peptide |
| 中文名称 | 缺氧诱导基因2蛋白封闭多肽 |
| 英文别名 | C7orf68; chromosome 7 open reading frame 68; HIG 2; HIG2; HLPDA_HUMAN; Hypoxia-inducible gene 2 protein; Hypoxia-inducible lipid droplet-associated protein; Hypoxia-inducible protein 2, HILPDA. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Hypoxia > Hypoxia-Regulated Epigenetics and Nuclear Signaling > Cardiovascular/Immune > Hypoxia > Hypoxia regulated Metabolism > Pathways and Processes > Metabolism processes > Hypoxia |
| 亚细胞定位 | Lipid droplet. Secreted. Membrane; Single-pass membrane protein (Potential). |
| 组织特异性 | Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level). |
| 功能 | Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HIG2 is a 63 amino acid single-pass membrane protein that can be hypoxia induced by glucose deprivation. Expression of HIG2 is increased in cervical cancer cells but inhibited in renal cell carcinoma. When bound to the extracellular domain of frizzled-10, HIG2 enhances oncogenic Wnt signaling and its own transcription, which suggests HIG2 may function as an autocrine growth factor. HIG2 may be a candidate for development of molecular-targeting therapy and could serve as a prominent diagnostic tumor marker for patients with renal carcinomas. The gene encoding HIG2 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. |
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HIG2 Antibody Blocking Peptide(bs-15488P)-500ug
￥880
