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- Bioss
- bs-12976P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12976P |
| 英文名称 | ASAH1 Antibody Blocking Peptide |
| 中文名称 | 酸性神经酰胺酶1封闭多肽 |
| 英文别名 | AC; ACDase; Acid CDase; Acid ceramidase; Acid ceramidase precursor; Acid ceramidase subunit beta; Acylsphingosine deacylase; ASAH 1; ASAH; ASAH1; ASAH1_HUMAN; FLJ21558; FLJ22079; N acylsphingosine amidohydrolase (acid ceramidase) 1; N acylsphingosine amidohydrolase 1; N acylsphingosine amidohydrolase; N-acylsphingosine amidohydrolase; PHP; PHP32; Putative 32 kDa heart protein. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Metabolism > Lipid metabolism |
| 亚基 | Heterodimer of one alpha and one beta subunit. |
| 亚细胞定位 | Lysosome. |
| 组织特异性 | Broadly expressed with highest expression in heart. |
| 相似性 | Belongs to the acid ceramidase family. |
| 功能 | Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism. |
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ASAH1 Antibody Blocking Peptide(bs-12976P)-500ug
￥880
