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- bs-12944P
- 2025年10月16日
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500ug
| 产品编号 | bs-12944P |
| 英文名称 | DNAJC5 Antibody Blocking Peptide |
| 中文名称 | 半胱氨酸延伸蛋白α封闭多肽 |
| 英文别名 | CLN 4; CLN4; CLN4B; CSP; cysteine string protein alpha; Cysteine string protein; DJC5; DnaJ (Hsp40) homolog subfamily C member 5; DnaJ homolog subfamily C member 5; DNAJC 5; Dnajc5; DNAJC5A; DNJC5_HUMAN; NCL. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Synapse marker |
| 亚基 | Homodimer (Probable). Interacts with the chaperone complex consisting of HSC70 and SGTA (By similarity). |
| 亚细胞定位 | Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| 组织特异性 | Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. |
| 翻译后修饰 | Fatty acylated. Heavily palmitoylated in the cysteine string motif. |
| 相似性 | Contains 1 J domain. |
| 功能 | May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cysteine string proteins (CSPs) are synaptic vesicle-associated, secretory vesicle proteins that are involved in Ca2+-regulated exocytosis of synaptic vesicles and modulation of presynaptic transmembrane calcium fluxes in neuroendocrine and endocrine cell types. CSP contains a J-domain that binds HSP 70/HSC 70 chaperone ATPases and a membrane-targeting, palmitoylated cysteine-rich string region. CSPs may act as molecular chaperones in synapses, and mediate conformational folding of components of the vesicular exocytotic machinery. CSP is involved in the fine tuning of neurotransmission through its interaction with receptor-coupled trimeric GTP binding proteins (G proteins) and N-type Ca2+ channels. Two variants of CSP have been described: CSP1; and the 31 amino acid, C-terminally truncated isoform, CSP2. Subcellular fractionation of insulinoma cells shows CSP1 in granular fractions, while the membrane and cytosol fractions contain predominantly CSP2. The fractions also contain additional proteins, presumably CSP dimers. Furthermore, in various mammalian cell lines (including rat brain) CSP1 expression predominates CSP2 expression. |
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DNAJC5 Antibody Blocking Peptide(bs-12944P)-500ug
￥880
