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- bs-11665P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-11665P |
| 英文名称 | PICALM Antibody Blocking Peptide |
| 中文名称 | 磷脂酰肌醇结合网格蛋白组装蛋白封闭多肽 |
| 英文别名 | CALM; Clathrin assembly lymphoid myeloid leukemia; Clathrin assembly lymphoid myeloid leukemia protein; CLTH; LAP; Phosphatidylinositol-binding clathrin assembly protein; PICAL_HUMAN; PICALM. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation |
| 亚基 | Binds clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate. |
| 亚细胞定位 | Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalized with clathrin in the Golgi area. |
| 组织特异性 | Expressed in all tissues examined. |
| 相似性 | Contains 1 ENTH (epsin N-terminal homology) domain. |
| 功能 | Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
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PICALM Antibody Blocking Peptide(bs-11665P)-500ug
￥880
