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- bs-11658P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-11658P |
| 英文名称 | DBI Antibody Blocking Peptide |
| 中文名称 | 乙酰辅酶A结合蛋白封闭多肽 |
| 英文别名 | ACBD; ACBD 1; ACBD1; ACBP; ACBP_HUMAN; Acyl CoA binding domain containing 1; Acyl CoA binding protein; Acyl Coenzyme A binding domain containing 1; acyl coenzyme A binding protein; Acyl-CoA-binding protein; acyl-Coenzyme A binding domain containing 1; CCK RP; CCKRP; Cholecystokinin releasing peptide trypsin sensitive; DBI; Diazepam-binding inhibitor; endozepine; EP; GABA receptor modulator acyl Coenzyme A binding protein; GABA receptor modulator. |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Types of disease > Obesity Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Neuroscience > Neuropharmacology > Molecular Neuropharmacology |
| 亚基 | Monomer. |
| 亚细胞定位 | Endoplasmic reticulum. Golgi apparatus.Note=Golgi localization is dependent on ligand binding. |
| 组织特异性 | Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart. |
| 相似性 | Belongs to the ACBP family. Contains 1 ACB (acyl-CoA-binding) domain. |
| 功能 | Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace Diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes Diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
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DBI Antibody Blocking Peptide(bs-11658P)-500ug
￥880
