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- bs-2133P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-2133P |
| 英文名称 | AGTR2 Antibody Blocking Peptide |
| 中文名称 | 血管紧张素Ⅱ受体2封闭多肽 |
| 英文别名 | AGTR 2; AGTR2; AGTR-2; AGTR2_HUMAN; angiotensin II receptor type 2; Angiotensin II Type 2; Angiotensin II type-2 receptor; Angiotensin receptor 2; AT 2; AT2; AT2R2 ATGR 2; ATGR2; ATGR-2; MRX 88; MRX88; Type 2 angiotensin II receptor; Type-2 angiotensin II receptor. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Atherosclerosis > Apoptosis Cardiovascular > Blood > Blood Pressure regulation Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR Signal Transduction > Signaling Pathway > Lipid Signaling > PLC |
| 亚基 | Interacts with MTUS1. |
| 亚细胞定位 | Cell membrane. |
| 组织特异性 | In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Very highly expressed in fetal kidney and intestine. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLC?is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites. |
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AGTR2 Antibody Blocking Peptide(bs-2133P)-500ug
￥880
