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- Bioss
- bs-15462P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-15462P |
| 英文名称 | HERC4 Antibody Blocking Peptide |
| 中文名称 | HERC4 E3泛素蛋白连接酶封闭多肽 |
| 英文别名 | DKFZP564G092; HECT and RLD domain containing E3 ubiquitin protein ligase 4; HECT domain and RCC1 like domain containing protein 4; HECT domain and RCC1-like domain-containing protein 4; Hect domain and RLD 4; HERC 4; HERC4; HERC4_HUMAN; KIAA1593; Probable E3 ubiquitin protein ligase HERC4; Probable E3 ubiquitin-protein ligase HERC4. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > Hect E3 Ligase |
| 亚细胞定位 | Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution. |
| 组织特异性 | Expressed in brain and testis and detected in heart and placenta.[DEVELOPMENTAL STAGE] Expressed in fetal brain. |
| 相似性 | Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 7 RCC1 repeats. |
| 功能 | Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]). |
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HERC4 Antibody Blocking Peptide(bs-15462P)-500ug
￥880
