- ￥880
- Bioss
- bs-14140P
- 2025年10月16日
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500ug
| 产品编号 | bs-14140P |
| 英文名称 | CYFIP2 Antibody Blocking Peptide |
| 中文名称 | 细胞质FMR1相关蛋白2封闭多肽 |
| 英文别名 | CYFP2; cytoplasmic FMR1 interacting protein 2; KIAA1168; p53 inducible protein; p53-inducible protein 121; PIR121; CYFP2_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Apoptosis > Intracellular > p53 Pathway Immunology > Adaptive Immunity > T Cells > Non-CD Neuroscience > Neurology process > Neurodegenerative disease |
| 亚基 | Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. |
| 亚细胞定位 | Cytoplasm. Cytoplasm, perinuclear region. Cell junction , synapse, synaptosome. Note: Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. |
| 组织特异性 | Expressed in T-cells. Increased expression is observed in CD4+ T-lymphocytes from patients with multiple sclerosis (at protein level). |
| 相似性 | Belongs to the CYFIP family. |
| 功能 | Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CYFIP2 is involved in T cell adhesion and p53 dependent induction of apoptosis. It does not bind RNA but is up regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis. There are 2 isoforms produced by alternative splicing. |
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CYFIP2 Antibody Blocking Peptide(bs-14140P)-500ug
￥880
