- ￥880
- Bioss
- bs-11603P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11603P |
| 英文名称 | TBR1 Antibody Blocking Peptide |
| 中文名称 | TBR1蛋白封闭多肽 |
| 英文别名 | T-box brain protein 1; TBR1_HUMAN; T-brain-1; TBR-1; TES-56 |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neural Signal Transduction Neuroscience > Neurology process > Neurogenesis |
| 亚细胞定位 | Nuclea |
| 组织特异性 | Brain. |
| 相似性 | Contains 1 T-box DNA-binding domain. |
| 功能 | Probable transcriptional regulator involved in developmental processes. TBR1 is required for normal brain development. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | A novel murine and human gene, TBR-1, encodes a putative transcription factor related to the Brachyrury (T) gene that is expressed only in postmitotic cells. T-brain-1 (TBR-1) mRNA is largely restricted to the cerebral cortex, where, during embryogenesis, it defines different regions that give rise to the palecortex, limbic cortex and neocortex (1-3). TBR-1, Pax-6 and Emx-1 are expressed in the mouse and chicken pallium. The pallio-subpallial boundary lies at the interface between the TBR-1 and Dlx-2 expression domains. Chicken genes homolgous to these mouse genes are expressed in topologically comparable patterns during development, suggesting that mouse and chicken may have similar histogenetic specification processes and field homologies (4). CASK/LIN-2, a membrane-associated guanylate kinase, is required for EGFR localization and signaling. In adult rat brain, CASK is concentrated at neuronal synapses and binds to the cell-surface proteins. CASK can interact with TBR-1, which is involved in forebrain development. CASK enters into the nucleus and binds to a specific DNA sequence (the T-element) in a complex with TBR-1. Thus, CASK acts as a coactivator of TBR-1 to induce transcription of T-element containing genes, including reelin (5). |
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TBR1 Antibody Blocking Peptide(bs-11603P)-500ug
￥880
