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- Bioss
- bs-15449P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-15449P |
| 英文名称 | HEG1 Antibody Blocking Peptide |
| 中文名称 | HEG同源蛋白1封闭多肽 |
| 英文别名 | HEG; HEG1; HEG1_HUMAN; KIAA1237; MST112; MSTP112; HEG homolog 1; Protein HEG homolog 1. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Angiogenesis > Growth Factors Cardiovascular > Heart > Cardiogenesis > Transcription factors/regulators Developmental Biology > Organogenesis > Angiogenesis and vasculogenesis Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Tight Junctions Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Binding Proteins |
| 亚基 | Interacts with CCM2 and KRIT1; KRIT1 markedly facilitates interaction with CCM2. |
| 亚细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction. Isoform 2: Secreted (Potential). |
| 相似性 | Contains 2 EGF-like domains. |
| 功能 | Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HEG1 (HEG homolog 1) is also known as HEG and is a 1,381 amino acid protein that exists as two alternatively spliced isoforms, one of which is a single-pass membrane protein and the other of which is secreted. HEG1, which is expressed in endothelial cells and smooth muscle cells of heart tissue, contains two EGF-like domains that play a role in calcium-binding events which may regulate concentric heart growth. The gene encoding HEG1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. |
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HEG1 Antibody Blocking Peptide(bs-15449P)-500ug
￥880
