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- bs-16914P
- 2025年10月16日
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500ug
| 产品编号 | bs-16914P |
| 英文名称 | KCNQ5 Antibody Blocking Peptide |
| 中文名称 | 电压门控钾通道亚基Kv7.5封闭多肽 |
| 英文别名 | KCNQ 5; KCNQ5; KCNQ5_HUMAN; KQT like 5; KQT-like 5; Kv7.5; OTTHUMP00000064152; OTTHUMP00000064153; Potassium channel alpha subunit KvLQT5; Potassium channel protein; Potassium channel subunit alpha KvLQT5; Potassium voltage gated channel KQT like subfamily member 5; Potassium voltage gated channel subfamily KQT member 5; Potassium voltage-gated channel subfamily KQT member 5; Voltage gated potassium channel subunit Kv7.5; Voltage-gated potassium channel subunit Kv7.5. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > Potassium Channels |
| 亚细胞定位 | Membrane. |
| 组织特异性 | Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus. |
| 相似性 | Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. |
| 功能 | Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
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KCNQ5 Antibody Blocking Peptide(bs-16914P)-500ug
￥880
