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- bs-16901P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-16901P |
| 英文名称 | KCNK18 Antibody Blocking Peptide |
| 中文名称 | 钾离子通道蛋白18封闭多肽 |
| 英文别名 | K2p18.1; KCNK18; KCNKI_HUMAN; MGR13; OTTHUMP00000020575; Potassium channel subfamily K member 18; TRESK 2; TRESK; TRESK2; TRIK; TWIK related individual K+ channel; TWIK related individual potassium channel; TWIK related spinal cord K+ channel; TWIK related spinal cord potassium channel; TWIK-related individual potassium channel; TWIK-related spinal cord potassium channel. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > GPCR > More GPCR Neuroscience > Neurotransmission > Receptors / Channels > Potassium Channels Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane. |
| 组织特异性 | Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord. |
| 翻译后修饰 | Phosphorylation of Ser-252 is required for the binding of 14-3-3eta/YWHAH. Calcineurin-mediated dephosphorylation of Ser-264 enhances channel activity. N-glycosylated. |
| 相似性 | Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. |
| 功能 | Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011] |
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KCNK18 Antibody Blocking Peptide(bs-16901P)-500ug
￥880
