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- Bioss
- bs-11595P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11595P |
| 英文名称 | NOMO1 Antibody Blocking Peptide |
| 中文名称 | NOMO蛋白封闭多肽 |
| 英文别名 | Nodal modulator 1; NOMO 1; Nomo; NOMO1; NOMO1_HUMAN; PM5; pM5 protein; pM5 protein telomeric copy. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein |
| 组织特异性 | Expressed in colon tumor tissue and in adjacent normal colonic mucosa. |
| 功能 | May antagonize Nodal signaling. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Three highly similar proteins termed NOMO1, NOMO2 and NOMO3, are encoded by a gene mapping to a region of duplication on the p arm of human chromosome 16. All three NOMO proteins share similar functions and have been difficult to characterize individually. NOMO1 (Nodal modulator 1), also known as PM5, is a 1,222 amino acid highly conserved single-pass type I membrane protein expressed in colon tumor tissue and normal colonic mucosa. NOMO proteins are novel antagonists of Nodal signaling which interact with Nicalin to form a Nicalin-NOMO complex, and are rapidly degraded or stabilized by Nicalin. NOMO proteins were once considered candidates for the development of pseudoxanthoma elasticum (PXE), a heritable disorder of connective tissue, as the NOMO genes are located in close proximity to the gene responsible for PXE development (MRP6). |
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NOMO1 Antibody Blocking Peptide(bs-11595P)-500ug
￥880
