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- Bioss
- bs-11594P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11594P |
| 英文名称 | NCLN Antibody Blocking Peptide |
| 中文名称 | γ-分泌酶组件蛋白NCLN封闭多肽 |
| 英文别名 | NCLN; NCLN_HUMAN; NET59; Nicalin; Nicalin homolog (zebrafish); Nicastrin like protein; Nicastrin-like protein. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Embryogenesis > Axis formation and symmetry Developmental Biology > Embryogenesis > Morphogens Signal Transduction > Growth Factors/Hormones > TGF |
| 亚基 | Forms a complex with NOMO2 and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex. |
| 亚细胞定位 | Endoplasmic reticulum membrane. |
| 组织特异性 | Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. |
| 相似性 | Belongs to the nicastrin family. |
| 功能 | May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGF beta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype. |
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NCLN Antibody Blocking Peptide(bs-11594P)-500ug
￥880
